[Medical Care] World’s First “Cancer Treatment Vaccine” to be Realized Nearly mRNA to Treat Brain Infarction and Cardiac Disease
“Cancer” is a disease that affects one out of every two Japanese people.
A vaccine that “treats” rather than “prevents” cancer will be widely available by 2030, according to a German biotechnology company that was involved in the development of a vaccine for the new coronavirus.
Technology for developing a vaccine for the new coronavirus is also being used in cancer research.
The world’s first “cancer vaccine” is being developed by the German biotech company Biontec. The company is known for having developed a vaccine for the new coronavirus together with Pfizer Inc.
In October 2022, its top executives appeared on the BBC program in the UK and said that “vaccines for the treatment of cancer will be widely available by 2030.
https://newsdig.tbs.co.jp/articles/-/190569?display=1
“I see AstraZeneca and Moderna are finally experimenting with putting mRNA directly into the heart.
Too bad.”
This is going to revolutionize the development of new drugs faster and more reliably.
“Originally, mRNA gene therapy drugs for cancer treatment.
We haven’t had success until now, but I wonder if we’re on the verge.
I thought all the clinical trials had failed.”
“I’m sure they’re developing them in Japan.
Also, there is no safe vaccine.”
I don’t think we’ll suddenly have something that works against all malignancies, but still, that’s progress.
Have you had success in clinical trials?
“It’s a gene delivery therapy that’s been in development for a while.
What’s a cancer vaccine now?”
A 30-year-old male has a 0.5% chance of being diagnosed with cancer by age 40, 10 years from now. This probability is only 2% 20 years later at age 50, and 7% 30 years later at age 60. Statistically, to put it in perspective, the probability of getting cancer in the working age population before age 60 is less than 1 in 10.
“I haven’t had the Corotin vaccine, but you should support this kind of future challenge.
Corotin is just scary because it hasn’t completed clinical trials.”
“I know they’re going to use mRNA to increase the production of parts that are only found in cancer cells to make antibodies.
Is it that easy to analyze?”
“Cancer cells are normal cells with torn telomeres and broken DNA.
Or there are also viral cancers.
So it’s not a panacea for all cancers.”
It’s going to be a standard treatment.
“NK cells, which are innate immune cells that get rid of ruined cells, and killer T cells, which are acquired immune cells.
Thousands of cancer cells are born every day, even in young people, but these immune cells get rid of them so they don’t develop the disease.
As immunity declines and immune cells that eliminate cells decline, the number of cancer cells that cannot be eliminated increases, leading to the onset of the disease.
Vaccines are designed to stimulate the immune system in some way.
Maybe the killer T cells attack the cancer cells.
It’s not a new mechanism, and this has been under development for some time.”
Cancer treatment is a bit of an article, but it’s about time it was implemented inexpensively.
“If you’re dying of cancer right now, that’s good news…
I’m sure they’d love to try it, even if they have to be the test subject.
I hope it works.”
“Anyone who wants to live longer should take it.
I’m not going to get cancer treatment because there’s a chance I’m going to suffer and die.”
“Not all cancers are like that.
Some are almost 100% curable with treatment.
It’s dangerous to say no because you have cancer.”
“I’m afraid of not being cured.
I’m afraid of not being cured, because cancer that has been exposed to anticancer drugs or radiation even once is more aggressive than cancer that has developed naturally.
If that’s the case, I’d rather accept death and die as comfortably as possible.”
“I work a lot with death certificates.
Most people die of cancer every day.
If you’re going to end up dying from cancer, you might as well try anything, even if it’s harmful.”
“They say that one in two people will get cancer.
People used to die before they got cancer because they lived too fast.”
Cancer will die if left alone, so I guess it’s mRNA that finally strikes when it gets to that stage.
“It’s like a drug that rewrites the genes of certain cancer cells to stop them from growing.
Well, it’s a possible cure, and it’s worth the risk.”
“Anticancer drugs and radiation therapy. Well, none of them.
It seemed to work for the ones that worked!”
Normally, cancer cells are born every day, but they are just suppressed so that they don’t multiply.
“By the way, this is a gene therapy drug (adenovirus vector) for spinal muscular atrophy that was approved two years ago in Japan.
This is the kind of price w
https://answers.ten-navi.com/pharmanews/18401/
Long-term efficacy with a single administration
On May 20, Novartis Pharma’s gene therapy drug for spinal muscular atrophy (SMA), Zorgensma (generic name: onasemnogen abeparvovec), was listed in the NHI drug price list and covered by insurance. The NHI drug price is 167,707,222 yen per patient. This is the highest unit price in Japan and the first “over 100 million yen” new drug in Japan.
SMA is a hereditary intractable disease caused by a functional defect in the SMN1 gene (SMN = Survival of Motor Neuron = motor neuron). Insufficient production of SMN protein, which is necessary for the normal function of motor neurons, leads to degeneration and loss of spinal cord progenitor cells that innervate skeletal muscles, resulting in muscle atrophy and loss of muscle strength. In the case of Type I (infantile form), which develops by the age of six months, more than 90% of patients die or require permanent respiratory management by the age of 20 months.
Sorgensma is a gene therapy that incorporates the SMN1 gene, the root cause of SMA, into adeno-associated virus (AAV). By supplementing the normal gene, the SMN protein is produced, improving vital signs and motor function. The administered SMN1 gene is designed to remain stable for a long period of time, and a single dose is expected to have a long-lasting effect.”
Originally, mRNA was supposed to be primarily used for cancer therapy. If this becomes controllable, that would be a new step forward in cancer treatment.
“Personalized vaccines?
It would be effective.
The cost would be at the billion-yen level.
It’s impossible with Japan’s universal health insurance.”
“There’s too much precedent for this kind of drug price to recover development costs.
The cost of supplies is like free.”
“Nucleic acid cancer drug discovery.
You know, Pfizer…
Pfizer failed three times and withdrew from the field.
It’s difficult, it’s difficult.
I don’t think we can do it just because we have a little bit of money.
I don’t think we can do it, even if we get a little bit of money.
I wonder why they’re so hung up on cancer.”
“I remember when some people’s cancer went into remission in clinical trials.
Stage 3 or so.
It seemed like it was worth a try.”
I heard that in the U.S., they cured a guy in the last stage.
“That’s great news.
Frankly, it’s better than the symptom-based treatments we’re wasting our time with.
I’d rather have this than the symptomatic, futile treatment we have now.
My aunt died of cancer from peritoneal technical myxoma.
She was on gastric lavage for two years.
“It’s like I’m almost certain I’m going to get cancer.
I have a lot of cancer insurance because I come from a cancer family.
I’ve got relatives under 60 who’ve had strokes and brain infarctions and cancer.
I’m terrified.”
“It depends on what kind of cancer they’re dying from.
If it’s a lot of stomach cancer, you should suspect H. pylori, or maybe it’s from lifestyle diseases.”
“I’m sure terminally ill patients would love to jump on the bandwagon.
It hasn’t been approved in Japan.
If you want to believe in the possibility and become a human test subject
you have to go to Germany.
I wonder how much it would cost for travel, hospitalization, accommodation, etc.”
“So you’re going to make it for that cancer and attack it.
That sounds more effective than cancer drugs.
I wonder how much it will cost.”
Since vaccines can be made in large quantities, it should be possible to do it on a national level at a very low cost.
“Thanks to all those people who have been vaccinating people, we’re going to be able to cure the mainstay of cancer.
I’ll do it when I can’t turn my back on it.”
(The saying, “You can’t change your back” means, “You have no choice but to do things in order to avoid an imminent situation.”)
The side effects of a vaccine can be considered a cure for cancer and other incurable diseases, and the returns can be quite significant.
“Sounds risky, though.
First of all, if the delivery mechanism to the cells is the same, you have to immunosuppress them first.
Even if you can make the antigen successfully, if you continue to do that and you get self-tolerance, the cancer will go all the way.”
“I do think we need drugs and treatments to overcome juvenile cancers.
What about cancer after the children have been raised and the grandchildren are grown…
Cancer may be one of the few ways to live without dementia.
With that in mind…
Maybe ‘a drug that completely eliminates the pain of cancer’ is better than ‘a drug for cancer’…”
“Prevent cancer when you can prevent Alzheimer’s disease.
Sometimes people who are supposed to die from cancer don’t die from cancer, and end up with dementia.
I’d rather die of cancer than have dementia.”
The Alzheimer’s drug that was developed a year ago was rejected a few days later because they said it didn’t work.
“If mRNA is completely degraded, it’s when liposomes containing mRNA autophagize.
Once it’s in the cell, it can’t be eaten by the innate immune system.
The coronavirus vaccine is like that.”
“It’s like a personalized cure.
A cure for the rich.
Poor people should just stick with what they’ve always had.”
“I had breast cancer in my 30s and had genetic testing.
I don’t know now if it was a factor in my cancer, but there was some weird gene in my genes.
Now I’m working as usual, but the fear of recurrence is still there.
I hope they figure things out and find a cure.”
“My own mother passed away last month. She developed uterine cancer from colon cancer, and in July of this year, she started to lose her ability to eat and became very weak.
I took a leave of absence from work to take care of her for a month.
The visiting doctor put her on a 24-hour high-calorie nutritional supplements drip, Dictortape for pain relief, and finally injections of narcotics for pain relief, but now she started to itch, and for about five days before it went away, she was itching and scratching all over, and it was painful to watch…
It made me think a lot…”
“To be frank, mRNA products will not be free from drug damage unless we can do something about the individual dependence on the amount of antigen.
Unless we can do something about the fact that mRNA drugs are dependent on the amount of antigen in each individual.
Yes, some people will overdose, but on average, it has to be this much to be significant and effective.
That’s what we’re trying to figure out, and that’s what we’re trying to determine the mRNA dose.”
“Someone here said that the gas pedal and brake could be done mechanistically if you do 10 years of research.
What we have now is a prototype that can’t be controlled in any way.”